Kinesin-1 Acts Independently and Also Regulates Kinesin-3-Dependent Transport of Synaptophysin Vesicles in Mammalian Axons
نویسندگان
چکیده
منابع مشابه
Kinesin-mediated transport of neurofilament protein oligomers in growing axons.
We examined cytoskeleton-associated forms of NF proteins during axonal neuritogenesis in cultured dorsal root ganglion (DRG) neurons and NB2a/d1 neuroblastoma. In addition to filamentous immunoreactivity, we observed punctate NF immunoreactivity throughout perikarya and neurites. Immuno-electron microscopy revealed this punctate immunoreactivity to consist of non-membrane-bound 75 nm round/ovoi...
متن کاملDISC1 Regulates the Transport of the NUDEL/LIS1/14-3-3 Complex through Kinesin-1
Shinichiro Taya,1 Tomoyasu Shinoda,1 Daisuke Tsuboi,1 Junko Asaki,1 Kumiko Nagai,1 Takao Hikita,1 Setsuko Kuroda,1 Keisuke Kuroda,1 Mariko Shimizu,1 Shinji Hirotsune,2 Akihiro Iwamatsu,3 and Kozo Kaibuchi1 1Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya 466-8550, Japan, 2Department of Genetic Disease Research, Graduate School of Medic...
متن کاملKinesin transport: driving kinesin in the neuron
A plethora of cytoplasmic motors contribute to the directed transport of a wide range of cellular organelles and molecules. Recent studies have advanced our understanding of cargo attachment to motor molecules and the regulation of intracellular transport.
متن کاملStable Kinesin and Dynein Assemblies Drive the Axonal Transport of Mammalian Prion Protein Vesicles
Kinesin and dynein are opposite-polarity microtubule motors that drive the tightly regulated transport of a variety of cargoes. Both motors can bind to cargo, but their overall composition on axonal vesicles and whether this composition directly modulates transport activity are unknown. Here we characterize the intracellular transport and steady-state motor subunit composition of mammalian prio...
متن کاملMyosin-V, Kinesin-1 and Kinesin-3 cooperate in long-distance transport in hyphal growth of the fungus Ustilago maydis
Long-distance transport is crucial for polar growing cells, such as neurons and fungal hyphae. Kinesins and myosins participate in this, but their functional interplay is poorly understood. Here we investigate the role of kinesin motors in hyphal growth of the plant pathogen Ustilago maydis. Although the microtubule plus-ends are directed to the hyphal tip, out of all 10 kinesins analyzed, only...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.694